EPID 5480

Genetic Epidemiology

This introductory course integrates the disciplines of epidemiology and genetics. The methods of genetic epidemiology will be used to estimate genetic components and localize the genes and regions influencing human diseases and related phenotypes. Heritability will be assessed using twin and pedigree data. Linkage analysis will be used to find genetic regions using human family data and also animal model. Family- and population-based candidate gene and genome-wide association analyses will be used to find diseases associated genes. Multiple regression methods will be used to explore gene x gene and gene x environment interactions. Gene expression studies and public health genomics will be covered.

Units: 3.0